Critical Care Reviews

Critical Care Reviews

Current standard of care across critical illness, organized by treatment area — with the landmark trials and society guidelines behind each recommendation.

Each review summarizes how critically ill patients are managed today, area by area. Every dose, threshold, and figure is taken from the cited primary source (DOI + PMID) and reviewed by the DosePilot Medical Team. Pick a topic from the menu; the current evidence our reviews are built on is listed below.

Evidence & guideline basis

2026
Surviving Sepsis Campaign 2026Sepsis
129 statements: NEWS over qSOFA, β-lactam infusion & de-escalation upgraded, MAP ≥65. PubMed →
2025
AHA Part 11 — Post-Cardiac Arrest CareTTM
Target 32–37.5°C (COR 1), ≥36 h of active control. PubMed →
2025
ERC–ESICM — Post-Resuscitation CareTTM
Active fever prevention; delayed multimodal neuroprognostication. PubMed →
2025
SRLF–GFRUP — RRT in the ICUAKI & CRRT
45 statements on RRT timing, modality, dose, anticoagulation & weaning. PubMed →
2025
BigpAK-2 (Lancet)AKI & CRRT
Biomarker-guided KDIGO care bundle cut moderate–severe post-op AKI. PubMed →
2024
BLING-III (JAMA)Sepsis
Continuous vs intermittent β-lactam infusion; informed the strong-rec upgrade. PubMed →
2024
ATS — ARDS Guideline UpdateARDS
Corticosteroids, VV-ECMO, neuromuscular blockade, higher PEEP. PubMed →
2024
SCCM — Corticosteroids Focused UpdateARDS
Conditional corticosteroids in ARDS, sepsis, and CAP. PubMed →
2023
CLOVERS (NEJM)Sepsis
Restrictive (vasopressor-first) fluids matched liberal in sepsis-induced hypotension. PubMed →
2023
Global Definition of ARDSARDS
Adds HFNO, SpO₂/FiO₂, and ultrasound to the criteria. PubMed →
2023
ESICM — ARDS GuidelinesARDS
21 GRADE recommendations across support strategies. PubMed →
2023
AABB 2023 Red-Cell Transfusion GuidelineTransfusion
Restrictive Hb 7 g/dL for most adults (8 ortho/CVD; 7.5 cardiac surgery). PubMed →
2023
MINT — Transfusion in Myocardial InfarctionTransfusion
Acute MI + anemia: liberal trend on primary; restrictive had higher cardiac death. PubMed →
2023
NUTRIREA-3 (Lancet Respir Med)Nutrition
Shock: early low calorie/protein speeds recovery vs standard targets. PubMed →
2023
EFFORT Protein (Lancet)Nutrition
High protein (≥2.2 g/kg) gives no benefit; possible harm in AKI. PubMed →
2021
TTM2 (NEJM)TTM
33°C vs targeted normothermia: no difference in mortality. PubMed →
2021
AKIKI-2 (Lancet)AKI & CRRT
Over-delaying RRT in severe AKI gave no extra benefit and signaled harm. PubMed →
2020
65 trial (JAMA)Sepsis
Permissive MAP 60–65 in patients ≥65 y cuts vasopressor exposure. PubMed →
2020
STARRT-AKI (NEJM)AKI & CRRT
Accelerated RRT gave no survival benefit and more dialysis dependence. PubMed →
2019
HYPERION (NEJM)TTM
33°C improved outcome after non-shockable arrest. PubMed →
2019
Subirà (JAMA)Mech vent
30-min pressure-support SBT yielded more extubations than T-piece. PubMed →
2018
PReVENT (JAMA)Mech vent
Non-ARDS: low vs intermediate tidal volume made no difference. PubMed →
2017
ART (JAMA)Mech vent
Aggressive recruitment + high-PEEP titration increased mortality. PubMed →
2015
PROPPR (JAMA)Transfusion
Massive hemorrhage: 1:1:1 vs 1:1:2 equal mortality, faster hemostasis. PubMed →
2011
EPaNIC (NEJM)Nutrition
Early parenteral nutrition harms; withhold supplemental PN to day 8. PubMed →
2010
CRASH-2 (Lancet)Transfusion
Tranexamic acid cuts bleeding death in trauma when given within 3 h. PubMed →
2009
NICE-SUGAR (NEJM)Nutrition
Tight glucose control (81–108) increases ICU mortality. PubMed →
2000
ARMA / ARDSNet (NEJM)Mech vent
Tidal volume 6 vs 12 mL/kg cut mortality — lung-protective ventilation. PubMed →

Disclaimer. Educational summaries for clinicians — not a substitute for individual clinical judgment or institutional protocols. Recommendation strengths are quoted from the cited guidelines; reviewed by the DosePilot Medical Team (Jun 2026).